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Losartan hctz generic Generic Controllability and the Efficacy of Tertiary Therapies in Cancer Treatment and Supportive Care, S. A. Lazzaro et al. This study was funded by the National Institutes of Health Office Cancer Research. Abstract Tertiary therapies may be relatively benign and inexpensive, as evidenced by the recent advances of low-dose cyclophosphamide and minoxidil. However, the relative benefit of low-dose cyclophosphamide and minoxidil in cancer management has not been well defined. This article presents a systematic review and meta-analysis of the efficacy these two drugs in different cancers with relevant end points as primary outcome parameters. Thirty-one articles containing 8,037 patients were identified, of which, 3 did not provide either single or mixed outcome data, whereas Losartan 60 Pills 37.5mg $249 - $4.15 Per pill 17 did. In general, low-dose cyclophosphamide and minoxidil were more effective than conventional or high-dose chemotherapy and supportive care. The magnitude of effect was not particularly different between patients who had primary (e.g. malignancies unrelated to radiation therapy) and secondary (e.g. malignancies associated with radiation treatment) malignancies. The median age of patients was relatively high: 75.5 years for low-dose cyclophosphamide, 78.6 minoxidil, and 81.5 years for high-dose chemotherapy and supportive care. We found no evidence that a greater number of patients enrolled in low-dose chemotherapy and supportive care studies was associated with a positive outcome. Low-dose cyclophosphamide and minoxidil were more efficacious when compared to high-dose chemotherapy and supportive care than when compared to conventional or low-dose chemotherapy and supportive care. There appears to be no benefit of low-dose cyclophosphamide and minoxidil in cancer management compared with conventional chemotherapy and supportive care. Introduction Current therapies for cancer include low-dose cyclophosphamide (which is the most efficacious primary therapy after a median of 3 years administration (15)) and minoxidil (a long-acting agent with efficacy that peaks 3.4–9 years after administration (19)) (4,20–24). Although these two drugs have been extensively studied in more than 100 clinical trials, there has been no long-term double-blind trial comparing their efficacy in cancer management (5,7,13,19,22,25). These pharmacological strategies are aimed at treating malignancies unrelated to radiation therapy, so it has not yet been determined whether these agents are beneficial in cancer patients receiving secondary treatment (16,16,16,16,16,17,19,25). The goal of this article is to systematically review and analyze the long-term efficacy of these two primary therapies. This was an aim of another systematic review and meta-analysis that appeared in 2009 (6). A common goal of these two systematic reviews, which involved 1,260 articles (6), was to provide high-quality evidence, but the two reviews also aimed to provide practical information clinicians, thus the article presents both systematic review and meta-analysis of this evidence. In the case of this analysis evidence, the objective was to determine whether low-dose cyclophosphamide and minoxidil are more efficacious than conventional chemotherapy losartan genericon 100 mg and supportive care in various cancers, including leukemia, advanced solid tumors, and non–small cell lung cancer. The primary outcome for these trials was a composite of primary tumor response as outcome and progression-free survival the secondary outcome. We analyzed 18 published observational studies that were conducted in 26 types of cancers. Fourteen the studies used low-dose cyclophosphamide (LC), 15 minoxidil (LDMT), and 5 had a mixed population (Table 1. Table 2. The main findings of this article are presented in Tables 3–5. Both low-dose cyclophosphamide and minoxidil were more efficacious at the end of protocol phase than conventional cancer treatment or supportive care (19,20–23). High-dose chemotherapy was considerably less efficacious in all tumor types, although more efficacious than low-dose chemotherapy in some cases. Although low-dose cyclophosphamide did not provide a definite benefit, at least one long-term randomized trial reported a reduction in the need for dialysis after low-dose cyclophosphamide (26). minoxidil showed no benefit in many trials (17,21–24). Table 3 Effect of Low-Dose Versus High-Dose Cycle Phosphamide and/or Minoxidil Versus Supportive Care in Different Types of Cancer. Author Patients (No.) Type of trial Low-Dose Cycle High-Dose Intervention Effect measure/group Main results Zuniga M et al.

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